Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of haemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anaemia.
Thalassemia is caused by variant or missing genes that affect how the body makes haemoglobin. Haemoglobin is the protein in red blood cells that carries oxygen. People with thalassemia make less haemoglobin and fewer circulating red blood cells than normal, which results in mild or severe anaemia. Thalassemia will be present as microcytic anaemia which may be differentiated from iron deficiency anaemia using the mentzer index calculation.
Thalassemia can cause significant complications, including iron overload, bone deformities and cardiovascular illness. However this same inherited disease of red blood cells may confer a degree of protection against malaria, which is or was prevalent in the regions where the trait is common. This selective survival advantage on carriers (known as heterozygous advantage) may be responsible for perpetuating the mutation in populations. In that respect, the various thalassemias resemble another genetic disorder affecting haemoglobin, sickle-cell disease.
Hemoglobin is made of two proteins: Alpha globin and beta globin. Thalassemia occurs when there is a defect in a gene that helps control production of one of these proteins.
There are two main types of thalassemia:
Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated).
Beta thalassemia occurs when similar gene defects affect production of the beta globin protein.
Alpha thalassemias occur most commonly in persons from southeast Asia, the Middle East, China, and in those of African descent.
Beta thalassemias occur in persons of Mediterranean origin, and to a lesser extent, Chinese, other Asians, and African Americans.
There are many forms of thalassemia. Each type has many different subtypes. Both alpha and beta thalassemia include the following two forms:
You must inherit the defective gene from both parents to develop thalassemia major.
Thalassemia minor occurs if you receive the defective gene from only one parent. Persons with this form of the disorder are carriers of the disease and usually do not have symptoms.
Beta thalassemia major is also called Cooley’s anemia.
(i) The most severe form of alpha thalassemia major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy).
(ii) Children born with thalessemia major (Cooley’s anaemia) are normal at birth, but develop severe anaemia during the first year of life.
Other symptoms can include:
(i) Bone deformities in the face
(iii) Growth failure
(iv) Shortness of breath
(v) Yellow skin (jaundice)
(vi) Persons with the minor form of alpha and beta thalassemia have small red blood cells (which are identified by looking at their red blood cells under a microscope), but no symptoms.
(i) Moon for blood and body fluids.
(ii) Mars for Blood disorders and RBC
(iii) Ketu – congenital disorder
(iv) Saturn-For chronic diseases.
(v) Lord of 6th ,8th and 12th bhava.
(vi)Venus- For body fluids.
(vii) Mercury- as it represents Tridosha in ayurveda.
Each planet governs specific body functions and parts of the anatomy:
Sun: Heart, Bones, Spine (and general vitality)
Moon: Blood, Stomach, Breasts, Body Fluids, Heart-Mind (Feelings/ Psychological)
Mars: Muscles, Circulation of Blood
Mercury: Nervous System, Skin, Speech, Intellect
Jupiter: Liver, Gall Bladder, Fat in the body
Venus: Uro-genital system, Kidneys, Hormones, Female organs
Saturn: Joints, Knees, Teeth
Additionally, the Natural Malefic planets, Mars, Saturn, Rahu, and Ketu, have areas of ill health that they specialize in:
Mars governs Accidents, Injury, Fevers and Infections, and Surgery
Saturn rules over Chronic Conditions, Debility, Exhaustion, and Depression
Rahu presides over Unusual Diseases, Poisons, Cancer, Loss of Consciousness
Ketu rules Mysterious Diseases, “Unseen” causes, i.e., Viruses and Parasites, and Karmic Diseases
Lord of sixth saturn is retrograde in 12th, while venus joint significator of body fluids is combust and retrograde. Mars as lord of 8th is conjunct lagna lord in 6th house. The native is born in shravana nakshatra of moon, moon as 11th lord is conjunct rahu and debilitated Jupiter badhak and suffering from kendra adhipati yoga. Lagna lord mercury is badly placed and in paap kartari yoga. Dispostor of moon ketu is significator of congenital disorder. Saturn aspects mars the significator of blood disorders and being retrograde it also aspects moon the dasha lord. Dasha at birth Moon-Ketu.
Lord of 6th and lagna venus is combust and in paap kaatari yoga and is conjunct 8th lord jupiter in sign cancer the nourishing sign governing body fluids along with signs of venus, there is an exchange between 1st and 3rd lord here. 8th lord jupiter is in maran karaka sthaan conjunct sixth lord in nakshtra of mercury along with Sun lord of 4th,venus the lagna and lord of 6th. Mercury as lord of 2nd is marak and in nakshatra of saturn the karka of all chronic diseases its conjunct rahu in 4th house. Mars occupies a marak house and is also owner of marak house the 7th, since the moon is in mrigshira dasha at birth is Mars ( governing blood disorders) it is also conjunct gulika in 2nd house, both mars and ketu are in nakshatra of rahu. This is a clear cut case of Thalassemia, dasha sequence was Mars-Mars-Saturn.
(i) 4th house affliction.
(ii) 4th lord affliction and bad aspects specifically of Saturn.
(iii) Gulik in second house.
(iv) Weak debilitated and combust jupiter.
(v) Venus combust and weak.
(vi) Lagna lord in Paap kartari yoga
(vii) Mars is functional malefic in both the horoscopes.